Publications

2023–24

Perilesional Epigenomes Distinguish Melanocytic Nevus Subtypes

Fall 2023 | Journal of Investigative dermatology

Michael Scherzer, Dekker Deacon, Robert Judson-Torres

Commentary on recent JID publication that describes differential methylation in normal skin adjacent to different nevus subtypes

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2022–23

Transposon Mutagenesis Reveals RBMS3 Silencing as a Promoter of Malignant Progression of BRAFV600E-Driven Lung Tumorigenesis

Fall 2022 | Cancer Research

Vaishnavi A, Juan J, Jacob M, Stehn C, Gardner EE, Scherzer MT, Schuman S, Van Veen JE, Newberg JY, Liu A, Mann K, Adams DJ, Grossmann A, Mann MB, McMahon M.

Sleeping Beauty Mutagenesis screen to identify tumor supressors in BRAF-mutant Lung cancer

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2020–21

Inhibition of MEK1/2 Forestalls the Onset of Acquired Resistance to Entrectinib in Multiple Models of NTRK1-Driven Cancer

Fall 2020 | Cell Reports

Vaishnavi A, Scherzer MT, Kinsey CG, Parkman GL, Truong A, Ghazi P, Schuman S, Battistone B, Garrido-Laguna I, McMahon M.

Created new models of kinase-fusion driven lung cancer and studied their response to MAPKI

Chloroquine Sensitizes GNAQ/11-mutated Melanoma to MEK1/2 Inhibition

Winter 2020 | Clinical Cancer Research

Vaishnavi A, Juan J, Jacob M, Stehn C, Gardner EE, Scherzer MT, Schuman S, Van Veen JE, Newberg JY, Liu A, Mann K, Adams DJ, Grossmann A, Mann MB, McMahon M.

Studied the resistance mechanisms of uveal melanoma cells to the combination of MAPK- and autophaghy- inhibition

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2019–20

Mutationally- activated PI3K promotes de-differentiation of lung tumors initiated by the BRAF(V600E) oncoprotein kinase

Fall 2019 | eLife

J Edward van Veen , Michael Scherzer, Julia Boshuizen, Mollee Chu, Annie Liu, Allison Landman, Shon Green, Christy Trejo, Martin McMahon

Created a new mouse model to fluorescently tag BRAF and used it to study changes in the transcriptome

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2013–16

Suramin Protects against cisplatin-induced acute kidney injury

Winter 2016 | American Journal of Physiology Renal Pathology

Dupre, T., Doll, M., Shah, P., Sharp, C., Kiefer, A., Scherzer MT, Siskind, L.

Tested the efficacy of suramin to protect against cisplastin toxicities

Fibroblast-Derived Extracellular Matrices As An Alternative Cell Culture System That Increases Metastatic Cellular Properties

Fall 2015 | Plos One

Scherzer, MT, Waigel, S, Donninger H, Arumugam V, Zacharias, W, Clark, G, Siskind, L, Soucy, P, Beverly, L.

Created Fibroblast-derived Matrices to compare the cell biology of lung cancer cells in 2D vs 3D

The PIM family of oncoproteins are small kinases with huge implications in myeloid leukemogenesis and as therapeutic targets

Fall 2014 | Oncotarget

Saurabh K*, Scherzer, MT*, SHah, P, Mims, A, Lockwood, W, Kraft A, Beverly LJ.

Used in vitro and in vivo models of leukemia to test cooperation of all three PIM kinases to cooperate with MYC

Dissecting the In Vivo Leukemogenic Potency of BCLxl

Fall 2014 | Journal of Leukemia

Saurabh K*, Scherzer, MT*, Song A, Yip KW, Reed JC, et al.

Here we swapped BH domains of different BCL proteins to determine oncogenic potency

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